Clean Rooms
Your trusted one-stop partner for Clean Room solutions
We support customers across the globe in industries such as healthcare (hospitals, operating rooms), pharmaceuticals, biotechnology, gigafactories, automotive, food processing, and microelectronics.
Our cleanroom solutions comply with ISO 14644 standards (Cleanrooms and Associated Controlled Environments). We provide fast, straightforward installation while maintaining the highest performance and quality standards.
The Challenges of Clean Room HVAC
Clean room HVAC systems face the challenge of maintaining extremely stable and contaminant‑free environments while supporting highly sensitive manufacturing and research processes. This requires tight control of temperature, humidity, airflow, and pressure differentials—often far more precise than in conventional HVAC applications. At the same time, the system must continuously filter out particles, bacteria, and other contaminants, all while managing high air exchange rates and operating around the clock.
Another major challenge is ensuring that every component—filtration units, air handling systems, building elements, and controls—works together seamlessly to meet strict standards, such as ISO 14644 and GMP requirements. Achieving this level of integration while balancing energy efficiency, reliability, and regulatory compliance makes clean room HVAC one of the most complex and demanding segments in the industry.
SEMCO supports our customers with its comprehensive product portfolio
SEMCO offers one of the most comprehensive product portfolios in the industry. Because we design and manufacture our own systems, every solution reflects a deep understanding of these critical clean room requirements. With SEMCO, customers benefit from seamless integration across all system components—including filtration units, clean room building elements, high‑efficiency chillers, and air handling units—all engineered specifically for clean room performance.
SEMCO’s clean room solutions allow you to align all critical environmental parameters with the specific needs of your production processes, ensuring precise control and consistent air decontamination.
Our systems regulate air pressure, temperature, and humidity—and, most importantly, minimize contamination from fine dust, skin particles, and bacteria—keeping these impurities away from your products and processes.
Clean Rooms Challenges and Solutions
The Challenge
ISO 14644 -Contamination control in pharmaceutical manufacturing
Failure to maintain these standards can result in product contamination, batch losses, and regulatory non-compliance in these precision manufacturing processes.
The Solution
SEMCO energy recovery units equipped with a True 3Å wheel
SEMCO energy recovery units equipped with True 3Å wheel technology provide the contamination control necessary for ISO 14644 compliance while maintaining energy efficiency.
- 0.05% contaminant carryover rate: True 3Å wheels minimize particle transfer between exhaust and supply airstreams. This low transfer rate supports stringent cleanliness classifications.
- Proprietary anti-stick coating: This coating prevents particles ≥3 Ångstrom from accumulating on wheel media.
- Complete isolation: Contaminated exhaust air is expelled from units without the cross-contamination of supply air.
- Consistent performance: Reliable contamination control maintains compliance during continuous operation.
- Product quality protection: This trait prevents airborne contamination that could compromise sensitive manufacturing processes
The Challenge
Maintainance of critical environmental parameters
Clean room operations require stringent control of temperature, humidity, and pressure to maintain product integrity and regulatory compliance.
- Microbial growth: Humidity levels above optimal ranges create breeding conditions for mold, bacteria, and waterborne pathogens.
- Volatile Organic Compound (VOC) reactions: Humidity fluctuations may trigger unwanted chemical reactions in pharmaceutical compounds, potentially creating safety issues and violating FDA regulations.
- Component damage: Temperature and humidity variations can damage sensitive electronics (semiconductors, battery cells), resulting in millions of dollars in product loss.
- Process downtime: Contamination breaches and/or a loss of differential pressure can result in an environmental excursion, triggering an investigation and the possibility of having to requalify the clean room.
The Solution
SEMCO Ascendant Series
The SEMCO Ascendant has an active desiccant wheel that has more than three times the dehumidification capacity of a direct expansion cooling system.
- Ultra-low dewpoints: The Ascendant can achieve and maintain dewpoints as low as 20°F, providing maximum moisture control.
- Risk mitigation: Tight environmental control eliminates contamination and chemical reaction risks.
- Consistent performance: Precise conditions are maintained regardless of ambient weather variations.
- Customized DDC controls: The purpose-built direct digital control (DDC) system delivers pharmaceutical-grade precision.
The Challenge
Laminar airflow movement uniformity
Clean room operations depend on precise laminar airflow patterns through HEPA filtration systems to maintain contamination-free environments.
However, achieving uniform laminar flow faces significant technical obstacles that can compromise sterile conditions:
- Flow disruption sources: Personnel movement, process equipment, and facility infrastructure creates turbulence that disrupt unidirectional airflow patterns. These disturbances can extend six to ten times the obstruction height downstream before laminar conditions are reestablished.
- Velocity uniformity requirements: Maintaining ±20% velocity variation across filter faces while sustaining 90 fpm average velocity becomes increasingly difficult as filter loading increases and system resistance changes over time.
- Particle resuspension risk: Disrupted laminar flow creates low-velocity zones and recirculation areas where particles can settle and later become resuspended, potentially migrating into critical sterile work zones and compromising product integrity.
The Solution
SEMCO Energy Recovery Systems
SEMCO energy recovery wheels utilize precision-engineered fluted aluminum media designed specifically for laminar flow applications. The geometric configuration of the fluted media channels maintains flow attachment and minimizes boundary layer separation, ensuring consistent velocity profiles across the entire filter face.
- Flow optimization: Fluted aluminum construction provides superior flow straightening compared to conventional media, reducing turbulence intensity by up to 40%.
- Adaptive control: Integrated EC fan systems enable real-time airflow adjustment to maintain precise velocity requirements as system resistance varies.
- Performance benefits: SEMCO systems maintain velocity uniformity within ±15% variation while delivering measurable energy savings through optimized fan operation and heat recovery. This reduces both operational costs and contamination risk in clean room environments.
SEMCO Solutions Overview
Though 60 years of experience and world-class product development, FläktGroup SEMCO has offerings that will support every part of your critical project, from project planning to installation and commissioning and beyond with service plans and upgrade paths.